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Re: Sight for sore eyes: Stem Cell Research Restores Sight to the Blind
Sight for sore eyes
29th May 2009
In a world-first breakthrough, University of New South Wales (UNSW) medical researchers have used stem cells cultured on a simple contact lens to restore sight to sufferers of blinding corneal disease.
Sight was significantly improved within weeks of the procedure, which is simple, inexpensive and requires a minimal hospital stay.
The research team from UNSW’s School of Medical Sciences harvested stem cells from patients’ own eyes to rehabilitate the damaged cornea. The stem cells were cultured on a common therapeutic contact lens which was then placed onto the damaged cornea for 10 days, during which the cells were able to re-colonise the damaged eye surface.
While the novel procedure was used to rehabilitate damaged corneas, the researchers say it offers hope to people with a range of blinding eye conditions and could have applications in other organs.
A paper detailing the breakthrough appears in the high-impact journal Transplantation this week.
The trial was conducted on three patients; two with extensive corneal damage resulting from multiple surgeries to remove ocular melanomas, and one with the genetic eye condition aniridia. Other causes of cornea damage can include chemical or thermal burns, bacterial infection and chemotherapy.
“The procedure is totally simple and cheap,” said lead author of the study, UNSW’s Dr Nick Di Girolamo. “Unlike other techniques, it requires no foreign human or animal products, only the patient’s own serum, and is completely non-invasive.
The surgeon who carried out the procedure and managed the patients was UNSW senior lecturer, Dr Stephanie Watson.
"The operation is relatively non-invasive. The patient merely comes into the hospital for a couple of hours to have their eye prepared and the lens put in place, and then they're able to go home," she said.
“There’s no suturing, there is no major operation: all that’s involved is harvesting a minute amount – less than a millimeter – of tissue from the ocular surface,” said Dr Di Girolamo.
“If you’re going to be treating these sorts of diseases in third world countries all you need is the surgeon and a lab for cell culture. You don’t need any fancy equipment.”
Because the procedure uses the patient’s own stem cells harvested from their eye, it is ideal for sufferers of unilateral eye disease. However, it also works in patients who have had both eyes damaged, Dr Di Girolamo said.
“One of our patients had aniridia, a congenital condition affecting both eyes. In that case, instead of taking the stem cells from the other cornea, we took them from another part of the eye altogether – the conjunctiva – which also harbours stem cells.
“The stem cells were able to change from the conjunctival phenotype to a corneal phenotype after we put them onto the cornea. That’s the beauty of stem cells,” Dr Di Girolamo said.
The therapeutic contact lens used in the trial was of a type commonly used worldwide after ocular surface surgery. However, of the several brands on the market, only one was suitable for growing the stem cells.
“We don’t know why. It’s probably to do with the components the manufacturers have used in that particular lens,” Dr Di Girolamo said.
The researchers are hopeful the technique can be adapted for use in other parts of the eye, such as the retina, and even in other organs. “If we can do this procedure in the eye, I don’t see why it wouldn’t work in other major organs such as the skin, which behaves in a very similar way to the cornea,” Dr Di Girolamo said.
View the video on the procedure.
Source: http://www.unsw.edu.au/news/pad/article … cells.html
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When you see results like this you have to seriously wonder why it's not being properly funded.
Re: Sight for sore eyes: Stem Cell Research Restores Sight to the Blind
It does make you wonder Axl S.
Problem is, you got a bunch of religious idiots running around out there, thinking they know what God is, and you must put a stop to this, because we're playing God. The end game is making test tube babies just for the stem cells, then discarding the embryos.
It's certaintly possible, as is cloning, but I think the risk is worth the reward. There's so many diseases and ailments we could potentially cure with stem cell treatment. It could becoming the miracle, generations have been waiting for.
I think we have to play it out. I'd rather regret supporting it, than to live with the idea that I never gave it a chance, and cost millions their lives or way of life.
- monkeychow
- Rep: 661
Re: Sight for sore eyes: Stem Cell Research Restores Sight to the Blind
So we trust people in our community to have nukes (the gov) but not doctors to cure diseases?
Re: Sight for sore eyes: Stem Cell Research Restores Sight to the Blind
Pretty much. Let's also not forget we trust the banks with OUR money in these bailouts to turn around and give us loans, that they are refusing to give, and hoarding our cash.
But... doctors are too dangerous. More dangerous than our own MONEY. 
- monkeychow
- Rep: 661
Re: Sight for sore eyes: Stem Cell Research Restores Sight to the Blind
I mean I agree that humans have fundemtally questionable ethics at times, and I don't doubt that some abuse would occur. But my issue is that in other areas of society we tollerate that risk, and punish those who cross the line in order to reap the benifits, but for some reason on this one issue it's all too hard and too scary.
